Content:
Progesterone.
Decription:
Oral: Each soft-gel capsule contains: Progesterone 100 mg or 200 mg.
Vaginal: Each soft-gel capsule contains: Progesterone 200 mg.
Indications: Oral: Disorders associated with a progesterone deficit: pre-menstrual syndrome, menstrual irregularity, benign breast disease, pre-menopause.
Treatment of the menopause (as an adjuvant to oestrogen therapy).Infertility caused by luteal phase defect.Menace of abortion or prevention of recurrent spontaneous abortions due to diagnosed luteal phase defect.Menace of preterm delivery.
Vaginal: During In Vitro Fertilization cycles (IVF).
Menace of abortion or prevention of recurrent spontaneous abortions due to luteal phase defect.
Menace of preterm delivery.
Dosage:
Oral: The standard daily dosage regimen is 200 to 300 mg of progesterone taken in one or two doses, i.e. 200 mg in the evening at bedtime and another 100 mg in the morning, if needed.
In the case of luteal phase defect (pre-menstrual syndrome, menstrual irregularity, pre-menopause, benign breast disease): the treatment is administered over 10 days per menstrual cycle, usually from cycle days 17 to 26 inclusive.
In the treatment of the menopause: given that stand-alone oestrogen therapy is not recommended, progesterone may be used as an adjuvant, to be given during the last two weeks of the treatment sequence, followed by a one-week suspension of all replacement therapy, during which withdrawal bleeding may be observed.
In the case of threatened abortion or in the prevention of LPD-related recurrent spontaneous abortions: the usual daily dosage is 200 mg to 400 mg progesterone, spread over two doses, to be taken up until gestation week 12.
In the case of threatened preterm delivery: 400 mg of progesterone every 6 to 8 hours, depending on the clinical results obtained during the acute phase, followed by a maintenance dose (e.g. 3 x 200 mg a day) to be taken up until gestational week 36.
Vaginal: The usual daily dosage is 200 mg of progesterone (i.e. one 200 mg capsule or two 100 mg capsules taken in two doses, one in the morning and one in the evening), to be inserted deep into the vagina, with or without the help of an applicator. This dosage may be increased depending on the individual patient response.
In the case of partial luteal phase defect (dysovulation, irregular menstrual cycles): the daily dose is 200 mg progesterone, administered over 10 days per menstrual cycle, usually from cycle days 17 to 26.
In the case of infertility associated with total luteal phase defect (oocyte donation): the initial progesterone dose is 100 mg, administered on days 13 and 14 of the transfer cycle, followed by 100 mg of progesterone given in the morning and evening of cycle days 15 to 25. From day 26 onwards, in the event of conception, dosage is increased in weekly increments of 100 mg progesterone per day, to reach a maximum daily dose of 600 mg progesterone, spread over three doses. This dosage is maintained up until day 60.
In the case of luteal phase supplementation during IVF: treatment is initiated in the evening of the transfer, at a rate of 600 mg progesterone spread over three doses (morning, noon and evening).
In the case of threatened abortion or in the prevention of LPD-related recurrent spontaneous abortions: the usual daily dosage is 200 mg to 400 mg progesterone, spread over two doses, to be taken up until gestation week 12.
In the case of threatened preterm delivery: Active treatment: 200 mg - 300 mg x 2 - 3 times/day in 3 days. Maintain dosage: 100 mg - 200 mg/day till suppression of contraction.
