Indication
CLARITHROMYCINE 250 mg Film-coated tablet is used for treatment of infections due to susceptible micro-organisms: pharyngitis, tonsillitis, mouth infections, uncomplicated skin infections, acute maxillary sinusitis, bacterial exacerbation of chronic bronchitis, pneumonia, eradication of Helicobacter pylori in peptic ulceration, Mycobacterial infections due to M. avium in patients with HIV (+).
Ingredient
Clarithromycin ………………………………. 250mg
Excipients: q.s.f ………………… 1 film-coated tablet
Dosage:
Adult with normal renal and hepatic function:
Pharyngitis, tonsillitis, mouth infections, uncomplicated skin infections: 1 tablet twice a day.
Acute maxillary sinusitis, bacterial exacerbation of chronic bronchitis, pneumonia: 2 tablets twice a day.
Eradication of Helicobacter pylori in peptic ulceration:
clarithromycin 500 mg combined with omeprazole 20 mg and amoxicillin 1000 mg, all twice a day for 7 days;
Other triple therapy: clarithromycin 500 mg combined with lansoprazole 30 mg and amoxicillin 1000 mg, all twice a day for 7 days;
(Amoxicillin can be replaced with metronidazole 500 mg or tinidazole 500 mg). To ensure healing, it is recommended to further the triple treatment with omeprazole or lansoprazole for up to 3 weeks for patients with active duodenal ulcer, and for up to 3 to 5 weeks for patients with active gastric ulcer:
Omeprazole 20 mg per day, if the treatment is started by omeprazole.
Or lansoprazole 30 mg per day, if the treatment is started by lansoprazole.
Mycobacterial infections due to M. avium in patients with HIV (+):
Patients weighing over 50 kg: 2000 mg/day, divided into 2 doses per day.
Patients weighing under or equal to 50 kg: 1500 mg/day, divided into 2 doses per day.
Adult with renal insufficiency (creatinine clearance < 30 ml/mn):
- The dose should be reduced by half (250 mg of clarithromycin once a day or 250 mg of clarithromycin twice a day in more severe infections). For infections due to M. avium: 1000 mg/day.
Mode of administration: Oral route.
Side effects
Nausea, vomiting, diarrhea, gastralgia,…
Pregnancy: For precaution, clarithromycin should not be used during pregnancy except no alternative therapy is appropriate, particularly during the first trimester of pregnancy.
Breast-feeding: The breast-feeding is possible, but stop the lactation (or the drug) if gastrointestinal disturbances occur to newborn child.
Consult your doctor or pharmacist prior to starting or stopping a new medication
