Indication:
- For the reduction of thrombotic events in patients with recent myocardial infarction, recent stroke, or established peripheral arterial disease.
- Used prophylactically in patients at risk of thromboembolic disorders such as myocardial infarction, peripheral arterial disease and stroke.
- For acute coronary syndrome (unstable angina/non-Q-wave MI).
Active Ingredient:
Clopidogrel 75mg, Aspirin 75mg
DOSAGE AND ADMINISTRATION
NORPLAT-S (Clopidogrel+Aspirin) can be administered with or without food. The recommended dose is one tablet daily. NORPLAT-S (Clopidogrel+Aspirin) has been administered for up to one year.
ADVERSE EFFECTS
NORPLAT-S is generally well tolerated. However following are the few adverse effects reported during treatment.
Gastrointestinal disturbances: Diarrhea, abdominal pain, indigestion, nausea and heart burn.
Dermatological reactions: Rash, pruritus. Ephritic ion reactions: Edema, urticaria, asthma.
Following adverse effects were reported rarely: Increase bleeding tendency, gastrointestinal bleeding, gastric ulcers, severe neutropenia or agranulocytosis, thrombocytopenia, thrombotic thrombocytopenic purpura, aplastic anemia, membranous nephropathy with ephritic syndrome, loss of taste, acute arthritis.
CONTRAINDICATIONS
Clopidogrel+Aspirin combination is contraindicated in patients:
! Who have shown hypersensitivity to clopidogrel, aspirin or any component of the product. ! With active gastro-duodenal ulcers.
! With hypersensitivity to salicylates (bronchospasm, anaphylactic reactions).
! With haemorrhagic disease.
! With severe hepatic function impairment.
! Who are pregnant.
! Who are lactating.
